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Your questions, answered

ICOTYDE is a 200 mg once-daily pill for the treatment of adults and children 12 years and older who weigh at least 88 pounds with moderate to severe plaque psoriasis.

Talk with your doctor

Start by having a conversation with your doctor about treatment options. Together, you can decide whether ICOTYDE is right for you. Try to be as open and honest as you can. This helps your doctor understand what you’re experiencing and choose the right treatment for you.

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ICOTYDE is the first & only interleukin-23 receptor (IL-23R) targeted oral peptide in a once-daily pill. In plaque psoriasis, IL-23 is a protein that plays a key role in inflammation. When IL-23 binds with its receptor, inflammation can occur in the body. ICOTYDE targets the IL-23 receptor, which blocks IL-23 from binding. This prevents the release of inflammatory proteins.

Learn more about how ICOTYDE works here.

*The clinical significance of these findings is unknown.

The most common side effects at 4 months (16 weeks)

  • headache
  • nausea
  • cough
  • fungal infection
  • tiredness

These are not all the possible side effects of ICOTYDE. Talk to your doctor about all possible side effects.

In 2 clinical trials, more than 5 out of 10 people saw at least 90% clearer skin at 4 months (16 weeks).

Explore Results.

ICOTYDE is approved for adults and children 12 years and older who weigh at least 88 pounds with moderate to severe plaque psoriasis.

7 out of 10 adolescents had at least 90% clearer skin in just 4 months (16 weeks).

ICOTYDE is one pill, once a day.

When you wake up, take with water on an empty stomach at least 30 minutes before eating.

If you have trouble swallowing pills, see the Taking ICOTYDE page for more information.

If you miss a dose of ICOTYDE, take the dose as soon as you remember and go back to your regular schedule the next day.

Swallow ICOTYDE whole. Do not crush, split, or chew ICOTYDE pills.

Your ICOTYDE prescription is filled by a specialty pharmacy. A specialty pharmacy works closely with you, your doctor, and your insurance company to confirm your access and get you support and then ships the medication directly to your home.

Visit the Getting ICOTYDE page for more details.

Once you and your doctor have decided ICOTYDE is right for you, you could pay as little as $0 per month through the ICOTYDE withMe Savings Program.*

*For eligible patients using commercial insurance. Maximum program benefit per calendar year applies. Offer subject to change or end without notice. See program requirements at ICOTYDEwithMeSavings.com.

ICOTYDE withMe is a patient support program. It offers different resources at no cost to patients. It includes the ICOTYDE withMe Savings Program, a dedicated Nurse Guide,‡ a patient account, and other helpful resources that are specific to ICOTYDE.

Whether you need help understanding how to get your prescription filled or finding cost support options to help you pay for your treatment, ICOTYDE withMe has everything you may need to help you start and stay on track.

Learn more about ICOTYDE withMe.

The support and resources provided by ICOTYDE withMe are not intended to provide medical advice, replace a treatment plan you receive from your doctor or nurse, or serve as a reason for you to start or stay on treatment.

‡Nurse Guides do not provide medical advice. Please ask your doctor any questions you might have about your disease and treatment.